research use only Diagnostics

Research Use Only Diagnostics

Staff at Catachem have been pioneers in the early development of diagnostic reagents for use on automated equipment going back to the 1970’s, and the company continues to develop research versions of new reagents for future use in the human clinical laboratory.

Catachem’s diagnostic products have been evolving for the nearly 40 years that the company has been in business. Landmark papers by Catachem’s founder Luis P. Leon, on a UV glucose reagent have been cited in the scientific literature 43 times at a recent count. Some newer testing products in Catachem’s U.S. research portfolio include plasma free hemoglobin (PFH), ethylene glycol, methanol, and glutamate dehydrogenase all of which can be used on most the modern laboratory analyzers.

Human Diagnostics

Specialty Testing Products for Research Use

Plasma Free Hemoglobin (C462-0A)
Normal plasma should not contain free hemoglobin. If blood is taken from a patient and is processed or manipulated in any way (dialysis, heart pump, etc.), or if the patient has suffered intravascular hemolysis caused by a number of disease states, damage to the red blood cells will be evident as hemoglobin released into the plasma. Catachem has developed an extremely sensitive assay to accurately measure minimal amounts of hemoglobin that may be present in a plasma sample.

This test can be run on most clinical chemistry analyzers, unlike those in the past. The test is sensitive and accurate enough to measure hemoglobin at levels approaching 2 mg/dL (1.2 µmol/L) and demonstrates linearity on most analyzers to 100 mg/dL (60 µmol/L).

Ethylene Glycol – Quantitative Test (C504-0A)
Ethylene glycol is a key component in most antifreeze products. The ingestion of ethylene glycol can quickly poison the patient and lead to irreversible liver and kidney damage if not quickly diagnosed and treated. If ethylene glycol is shown to be present in a patient’s blood, treatment is relatively simple.

Catachem has developed an accurate quantitative test (C504-0A) that determines ethylene glycol levels. Values obtained on Catachem’s quantitative test reagent compare closely to values obtained on GC/MS methods (Am.J.Clin.Pathol. 2011, 136:165-6). Catachem’s product has been designed to effectively eliminate interferences from propylene glycol, a secondary component in some antifreeze products that is also used as an additive in some human foodstuffs.

NOTE: The antidote 4-methylpyrazole (fomepizole), shows no interference to a level of 120mg/L. A typical target range for treatment is 8 – 25mg/L.

(Annals of Clinical Biochemistry, Robson et al, 09, 2016)

Methanol – Quantitative Test (C604-0A)
Clinically diagnosing methanol poisoning has been challenging to do, since it usually requires the use of specialized GC equipment not always available in a clinical laboratory. Severe methanol intoxication can be fatal. Catachem’s methanol test reagent can be used on a regular clinical chemistry analyzer.

This test is linear to 100 mg/dL (31 mM/L) and shows no interference from ethanol to a concentration of 690 mg/dL (a human being is comatose at 400 mg/dL ethanol). A 29 sample correlation against a GC-FID method gave a Deming Regression equation of y=0.899x – 2.66, r = 0.982.

Ethylene Glycol – FasTox Test Kit (C504-0C)
This test is designed for the low-volume user for use on a simple spectrophotometer (340 nm wavelength). It provides three semi-quantitative tests, each with low and high controls. Every kit is designed for one-time use directly off the shelf with a shelf life of approximately 18 months.

Mirroring Catachem’s quantitative test formulation, it is not subject to common interferences like propylene glycol. The format of the kit involving the use of both low and high controls during each test run eliminates any need for additional calibration.

Methanol – FasTox Test Kit (C604-FQ)

Designed similarly to Catachem’s FasTox ethylene glycol test for the low-volume user, this 340 nm test for methanol is for use on a simple spectrophotometer. Three individual tests are packaged along with three low and three high controls, eliminating the need for additional calibration. This product has an 18-month shelf life.

*For research use only

The above products for research use only in the USA

Applies to all products

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