Staff at Catachem have been pioneers in the early development of diagnostic reagents for use on automated equipment going back to the 1970s, and the company continues to develop research versions of new reagents for future use in the human clinical laboratory.
Catachem’s DiscretPak™ products for human use have been evolving for the more than 30 years that the company has been in business. The majority of this reagent line is FDA 510K approved for use in the human laboratory. Landmark papers by Catachem’s founder, Luis P. Leon, on a UV glucose reagent have been cited 43 times, while research on a colorimetric version of this reagent have been cited 17 times as of January 2014. Some newer products, currently approved for research use only, include a plasma free hemoglobin (PFH) reagent that has been designed for use on a standard format clinical analyzer and a liquid ethylene glycol reagent for similar wet chemistry application.
Specialty Human Products
Plasma Free Hemoglobin (C462-0A)
This test can be run on most clinical chemistry analyzers, unlike those in the past. The test is sensitive and accurate enough to measure hemoglobin at levels approaching 2 mg/dL (1.2 µmol/L) and demonstrates linearity on most analyzers to 100 mg/dL (60 µmol/L).
Ethylene Glycol – Quantitative Test (C504-0A)
Catachem has developed an accurate quantitative test (C504-0A) that determines ethylene glycol levels. Values obtained on Catachem’s quantitative test reagent compare closely to values obtained on GC/MS methods (Am.J.Clin.Pathol. 2011, 136:165-6). Catachem’s product has been designed to effectively eliminate interferences from propylene glycol, a secondary component in some antifreeze products that is also used as an additive in some human foodstuffs.
NOTE: Neither diethylene glycol nor the antidote 4-methylpyrazole (fomepizole), the latter tested to a level of 3,000 mg/dL (30 g/L), showed any interference in the assay.
Methanol – Quantitative Test (C604-0A)
This test is linear to 100 mg/dL (31 mM/L) and shows no interference from ethanol to a concentration of 690 mg/dL (a human being is comatose at 400 mg/dL ethanol). A 29 sample correlation against a GC-FID method gave a Deming Regression equation of y=0.899x – 2.66, r = 0.982.
Ethylene Glycol – FasTox Test Kit (C504-0C)
Mirroring Catachem’s quantitative test formulation, it is not subject to common interferences like propylene glycol. The format of the kit involving the use of both low and high controls during each test run eliminates any need for additional calibration.
Methanol – FasTox Test Kit (C604-0B)
*For research use only
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